You can import a Substance file (.sbsar) in most major engines via the Substance Plugin.
- Unity has the substance plugin natively integrated for the 2017 release cycle. For Unity 2018 and higher, the Substance plugin is available in the Unity Asset Store.
- The UE4 plugin can be found on the Unreal Marketplace.
- The Lumberyard plugin is natively integrated.
- The Cryengine plugin is natively integrated and maintained by Crytek. For more information, please see the cryengine documentation here: https://docs.cryengine.com/pages/viewpage.action?pageId=44968527