On Windows, you can sometimes encounter this error:
"There is no disk in the drive. Please insert a disk into drive X."
There are a few things to check to get rid of this error:
- Verify that your drive letters setup is correct (see https://support.microsoft.com/en-us/kb/330137 )
- Verify that any previous location used in Substance Painter is valid (like the "recent Files" list)