Substance Painter cannot start because api-ms-win-crt-runtime-l1-1-0.dll is missing from your computer.
This is most likely because the update KB2999226 which is part of the Visual C++ Redistributable for Visual Studio 2015 failed to install.
How to fix the issue ?
1 - Verify that Windows is up to date
- Open the Start menu
- Select Control Panel
- Click on Windows Update
- Click on Check for updates
- Install all available updates.
- After the updates are installed, restart your computer.
After the restart repeat the steps above again until no more updates are available.