Some GPU configurations and/or GPU models are incompatible with Substance Painter and will lead to instabilities and crashes. Below is a list of the incompatible configurations :
Nvidia SLI / AMD Crossfire
|Disable SLI or Crossfire in the GPU driver settings.|
(Two GPU chipsets on one graphic card)
|Disable the use of the two GPU chipsets in the drivers settings to only one.|
This issue only affect the main engine of Substance Painter, Baking and Rendering (Iray) are compatible with multi-GPUs. Refer to their dedicated settings for more information.