You can view and/or modify all the proposed keyboard and mouse shortcuts in this panel. Click on the "pen" icon next to a shortcut to edit it (and enter you new combination).

For a quick overview of all the Shortcuts in Substance Painter you can head over the graphic available on Substance Academy.

Editable shortcuts

To reset a shortcut back to its default value simply right-clicking on it.

Action	Shortcut (Windows)	Shortcut (MacOS)	Description
Hide Interface	Tabulation	Tabulation	Hide all the panels of the interface to maximize the viewport(s).
Undo	Ctrl+Z	⌘+Z	Cancel the last action and go back to the previous one.
Redo	Ctrl+Y	⌘+Y	Go forward in the action list, redoing the action that has just been cancelled.
Mode Painting	F9	F9	Switch the interface to the Painting mode.
Mode Rendering (Iray)	F10	F10	Switch the interface to the Rendering mode.
Open project	Ctrl+O	⌘+O	Open the Operating System File open dialog to load a project.
Close project	Ctrl+F4	⌘+W	Close the currently opened project.
Save project	Ctrl+S	⌘+S	Save the currently opened project.
Save As project		Shift+⌘+S	Save the currently opened project. under a new name.
New project	Ctrl+N	⌘+N	Open the new project creation window.
Quit application	Alt+F4	⌘+Q	Close Substance Painter.

Increase tool size	]	]	Increase the size of the brush for the painting tool.
Decrease tool size	[	[	Decrease the size of the brush for the painting tool.
Invert grayscale tool	X		Invert the current grayscale value if the painting tool is on a mask.
Pick stroke material	P	P	Enable the material picker tool.
Symmetry	L	L	Enable the symmetry along a given axis.
Lazy Mouse	D	D	Enable the lazy mouse behavior on the current tool.

Swap 2D / 3D view	F4	F4	Swap between 2D and 3D view in viewport and 2D UV view.
Camera Perspective	F5	F5	Change the camera of the viewport to a Perspective view.
Camera Orthographic	F6	F6	Change the camera of the viewport to an Orthographic view.
Display next channel	C	C	Switch the viewport to the Solo view mode and display the next channel of the current Texture Set.
Display material	M	M	Switch the viewport to the Material rendering mode.
Display next mesh map	B	B	Switch the viewport to the Solo view mode and display the next mesh map of the current Texture Set.
Toggle particles animation	Space	Space	Pause/Unpause animation of the particles if a particle projection is in progress.
Export textures	Ctrl+Shift+E	Shift+⌘+E	Open the export textures window.
Center the whole mesh	F	F	Center the whole mesh of the current project in the middle of the viewport.
Toggle quick mask edition	U	U	Enter/Exit the quick mask edition.
Clear quick mask	Y	Y	Disable and clean the quick mask.
Invert quick mask	I	I	Invert the current values of the quick mask.
Viewport layout 3D/2D	F1	F1	Change the viewport display to show the 3D and 2D view.
Viewport layout 3D only	F2	F2	Change the viewport display to show only the 3D.
Viewport layout 2D only	F3	F3	Change the viewport display to show only the 2D.
Texture Set isolate	Alt+Q	Option+Q	Isolate the current Texture Set by hiding the other in the viewport.

Select Paint tool	1	1
Select Paint tool + Particles	Ctrl+1	⌘+1
Select Eraser tool	2	2
Select Eraser tool + Particles	Ctrl+2	⌘+2
Select Projection tool	3	3
Select Projection tool + Particles	Ctrl+3	⌘+3
Select Polygon Fill	4	4
Select Smudge tool	5	5
Select Clone tool (relative source)	6	6
Select Clone tool (absolute source)	Ctrl+6	⌘+6

Use tool / paint	Mouse left	Mouse left
Draw straight lines	Shift+Mouse left	Shift+Mouse left
Draw straight lines with snapping	Ctrl+Shift+Mouse left	Ctrl+Shift+Mouse left
Camera rotate	Alt+Mouse left	Option+left
Camera snap rotate	Alt+Shift+Mouse left	Shift+⌘+Mouse left
Camera translate	Alt+Middle mouse	Option+⌘+Mouse left
Camera translate (alternative)	Ctrl+Alt+Mouse left
Camera zoom	Alt+Mouse right	Mouse middle
Stencil rotate	S+Mouse left	S+Mouse left
Stencil snap rotate	Shift+S+Mouse left	Shift+S+Mouse left
Stencil translation	S+Middle mouse
Stencil zoom	S+Right mouse	S+Right mouse
Change tool Size / Hardness	Ctrl+Mouse right	⌘+Mouse right
Change tool Flow / Rotation	Ctrl+Mouse left	⌘+Mouse left
Rotate environment	Shift+Mouse right	Shift+Mouse right
Depth of Field Auto-Focus	Ctrl+Middle mouse
Texture set selection	Ctrl+Alt+Mouse Right	Option+⌘+Mouse right
Click in viewport Quick menu	Mouse right	Mouse right
Set Clone tool source location	V+Mouse left	V+Mouse left

Ignore stencil mask	N	N	Temporarily disable the stencil (avoid to remove it entirely)
Resume previous stroke	A	A	Allow to continue the previously created brush stroke to avoid discontinuities.

Non-Editable shortcuts

Some shortcuts may only work if the mouse is over the specific window. For example : copy and pasting requires that the mouse is over the layer stack.

Action	Shortcut (Windows)	Shortcut (MacOS)
Copy layer	Ctrl+C	⌘+C
Cut layer	Ctrl+X	⌘+X
Paste layer	Ctrl+V	⌘+V
Delete layer	Delete	Delete
Duplicate layer	Ctrl+D	⌘+D
Group layer	Ctrl+G	⌘+G
Copy layer content	Ctrl+Shift+C	Option+⌘+C
Paste layer content	Ctrl+Shift+V	Option+⌘+V
Display mask in viewport	Alt+Mouse left	Option+Mouse left
Disable/Enable mask	Shift+Mouse left	Shift+Mouse left
Cycle through the cameras	left or right arrow	left or right arrow

Manipulators' shortcuts for the triplanar projection:

Action	Shortcut (Windows)	Shortcut (MacOS)
Show/hide	Q	Q
Translate	W	W
Rotate	E	E
Scale	R	R
Change (object/world)	T	T
Decrease/Increase size	-/+	-/+

Manipulators' shortcuts for the UV projection:

Action	Shortcut (Windows)	Shortcut (MacOS)
Show/hide	Q	Q
Snapping On	Shift (hold)	Shift (Hold)
Symmetrical selection	Ctrl	⌘
Decrease/Increase size	-/+	-/+

Drag and drop materials and smart materials on a portion of a mesh:

Action	Shortcut (Windows)	Shortcut (MacOS)
Drag & drop	CTRL+Drag&Drop	⌘+Drag&Drop