Software conflicts

Here is the list of the known issues with other existing software that may crash or stops Substance Painter from starting up.

Software NameIssue
Anti-Virus / Anti-Spyware

Anti-virus or anti-spyware softwares can create some of the following issues:

  • False positive: the application is detected as being a virus (or similar) while it isn't.
  • Blocked files: the application cannot read or write files (export, preset creation, etc) or cannot activate a license.
  • Files deletion: the application cannot start or work normally because necessary files have been removed.

If one of these situations arise, we recommend to try disabling the anti-virus temporarily to see if it helps or even manually add exceptions. We ensure that our applications are virus-free. So if the installer has been downloaded from our official website, any warning is very likely a false positive.


Multiple GPU configurations are unsupported by Substance Painter, leading to crash during computations. We recommend to disable this feature.
Autodesk assistant applicationThe Autodesk assistant application can create conflict Substance Painter and make it crash at startup or when opening a project file. Update the Autodesk application to resolve the problem.
Alienware / Dell computerSee this page for more information : Crash when opening or saving a file
APFS by Paragon Software

This software may register a location in Windows Path environment variable that may crash the application at startup. Uninstalling the software may not be enough and the environment variable may need to cleaned up manually. Example of problematic location:

C:\Program Files (x86)\Paragon Software\APFS for Windows\ï–›éŒ à €è¸€ì‡ì‡ç¿¹


Having an older version of Avecto running can cause slowdowns and crashes. Make sure you update it to the latest version.
Asus GPU TweakThis software produce issues during the compilation of shaders within Substance Painter and prevent it to start. It is recommended to uninstall it.
Asus RAMCacheThis software may prevent Substance Painter to start properly or even make it unstable while working. We recommend to disable or uninstall it.

Asus Sonic Suite

On some computers with an ASUS Motherboard, a software named "Asus Sonic Suite" can be installed by default. Uninstalling this software can fix some display/interface issues in Substance Painter.

Cloud Backup Software
(OneDrive, GDrive, Dropbox, Filestream, etc)

Cloud backup software can be the source of numerous crash while saving a project. If that happens, it is recommended to work and save on a project file outside the synced folder by the application and instead copy the project back inside that folder once done.
ChituboxOn some computers, this software can create a conflict and crash the application when opening a file dialog (like opening or saving a project). It is recommended to either disable the setting Enable thumbnail preview of desktop model in its preferences or to uninstall it. 

Duet Display

The application Duet Display is known to create GPU drivers issues that can impact the behavior of Substance Painter. It is recommended to uninstall it.
Google ChromeGoogle Chrome can be the source of some crashes when running alongside Substance Painter. It is recommended to update Google Chrome and the GPU drivers to improve the stability of Substance Painter. If crashes still occurs, disable Hardware Acceleration in Google Chrome (which will disable the use of the GPU).

Nahimic audio software

On some other Dell computers the Nahimic audio software can freeze the application. Stopping it can help, it is also possible to avoid issues by updating it.

Openshot Video Software

Some software such as "Openshot Video Software" can create a conflict with Substance Painter with the previews of the shelf. We recommend to update the software to fix the issue.

Rptr /

On computers with an AMD GPU, there is a software named Rptr (or ) which is installed by default with the GPU drivers. This software can create instabilities and crash Substance Painter. It is recommended to uninstall it. 


This software can create conflicts with the Graphic Tablet drivers, it is recommended to stop the process or uninstall it.